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Extrahepatic Manifestations of Chronic HCV Infection

List of authors.
  • Patrice Cacoub, M.D.,
  • and David Saadoun, M.D., Ph.D.

Hepatitis C virus infection is associated with nonhepatic diseases, including mixed cryoglobulinemic vasculitis, B-cell lymphoma, cardiovascular diseases, type 2 diabetes, and renal dysfunction. Direct-acting antiviral agents that cure the underlying infection are associated with a reduced incidence of most of these diseases.

Funding and Disclosures

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Dr. Cacoub reports receiving lecture fees and advisory board fees from AbbVie, Gilead, GlaxoSmithKline, Vifor, and Merck Sharp & Dohme, advisory board fees from Innotech and Servier, grant support, lecture fees, and advisory board fees from Alnylam, and holding patent WO 2012/123381 A1 on low-dose interleukin-2 in autoimmune diseases, licensed to IL-2 Based Therapies, for which he receives royalties; and Dr. Saadoun, receiving lecture fees and advisory board fees from Celgene, grant support, advisory board fees, lecture fees, and travel support from AbbVie and Janssen, grant support, advisory board fees, lecture fees, travel support, and donated drugs from Sanofi Genzyme, grant support, advisory board fees, and lecture fees from Roche Chugai, grant support from Amgen and HifiBio, travel support from Mylan, and donated drugs from Sobi and GlaxoSmithKline, and holding patent WO 2012/123381 A1 on use of low-dose interleukin-2 for treating autoimmune related or inflammatory disorders, licensed to IL-2 Based Therapies, for which he receives royalties. No other potential conflict of interest relevant to this article was reported.

Author Affiliations

From the Department of Internal Medicine and Clinical Immunology, Assistance PubliqueCH?pitaux de Paris, Groupe Hospitalier Piti-Salptrire, Centre de Rfrence des Maladies Auto-Immunes Systmiques Rares and Centre de Rfrence des Maladies Auto-Inflammatoires et de lAmylose Inflammatoire, Institut National de la Sant et de la Recherche Mdicale UMR S 959, Centre National de la Recherche Scientifique FRE3632, and the InflammationCImmunopathologyCBiotherapy Department, Sorbonne Universit all in Paris.

Address reprint requests to Dr. Cacoub at the Department of Internal Medicine and Clinical Immunology, H?pital La Piti-Salptrire, 47-83, Blvd. de lH?pital, 75651 CEDEX 13, Paris, France, or at .

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