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Case Records of the Massachusetts General HospitalFree Preview

Case 8-2021: A 34-Year-Old Woman with Cholangiocarcinoma

List of authors.
  • Lipika Goyal, M.D.,
  • Christopher T. Chen, M.D.,
  • Theodore T. Pierce, M.D.,
  • and Vikram Deshpande, M.D.

A 34-year-old woman was evaluated in the oncology clinic for the management of recurrent, metastatic intrahepatic cholangiocarcinoma. Before evaluation, an extended right hepatectomy had been performed, and the patient had received adjuvant therapy with gemcitabine and cisplatin. When relapse of the cancer occurred, additional management decisions were made.

Funding and Disclosures

This case was presented at Cancer Center Grand Rounds.

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Dr. Goyal reports receiving grant support, paid to her institution, from Adaptimmune, Bayer, Bristol-Myers Squibb, Eisai, Leap Therapeutics, Loxo Oncology, MacroGenics, Merck, Novartis, NuCana, and Relay Therapeutics, grant support, paid to her institution, advisory board fees, and consulting fees from Agios, Incyte, Taiho Oncology, and QED Therapeutics, advisory board fees from AstraZeneca and H3 Biomedicine, consulting fees from Exelixis, grant support, paid to her institution, and consulting fees from Genentech, and advisory board fees and consulting fees from Alentis Therapeutics and Sirtex Medical; and Dr. Chen, receiving consulting fees from Foundation Medicine, Nuvelution Pharma, Blackstone Life Sciences, and HotSpot Therapeutics. No other potential conflict of interest relevant to this article was reported.

We thank Jennifer Stanton for her assistance in obtaining hospital records and Linda and David Fleischer for their partnership in caring for Sarah and for sharing their perspective as caregivers.

Author Affiliations

From the Departments of Medicine (L.G., C.T.C.), Radiology (T.T.P.), and Pathology (V.D.), Massachusetts General Hospital, and the Departments of Medicine (L.G., C.T.C.), Radiology (T.T.P.), and Pathology (V.D.), Harvard Medical School both in Boston.

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