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<tps:definition tag="charStyleDef"> <tps:charStyleDef> <tps:name>smallcap.bold</tps:name> <tps:basedOn>smallcap</tps:basedOn> <tps:font> <tps:name>OTNEJMQuadraatCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:definition> <tps:definition tag="charStyleDef"> <tps:charStyleDef> <tps:name>smallcap.bold.italic</tps:name> <tps:basedOn>smallcap.bold</tps:basedOn> <tps:font> <tps:name/> <tps:style>Bold Italic</tps:style> </tps:font> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:definition> <tps:definition tag="charStyleDef"> <tps:charStyleDef> <tps:name>smallcap.italic</tps:name> <tps:basedOn>smallcap</tps:basedOn> <tps:font> <tps:name/> <tps:style>Italic</tps:style> </tps:font> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:definition> <!-- =========================== --> <!-- Paragraph Style Definitions --> <!-- =========================== --> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>abstract</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>abstract</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>abstract</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>abstract2head</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>abstract2head</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>9 pt</tps:fontSize> <tps:leading>10.5 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>3.175 mm</tps:spaceBefore> <tps:nextStyle>abstract</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>abstracthead</tps:name> <tps:basedOn>head1</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>abstracthead</tps:name> <tps:basedOn>head1</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>abstracthead</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>affiliation</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>affiliation</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:spaceAfter>2.11667 mm</tps:spaceAfter> <tps:nextStyle>affiliation</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>affiliation.signedby</tps:name> <tps:basedOn>affiliation</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>affiliation.signedby</tps:name> <tps:basedOn>affiliation</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left</tps:alignment> <tps:spaceBefore>2.11667 mm</tps:spaceBefore> <tps:nextStyle>affiliation.signedby</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>affiliationnote</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>affiliationnote</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentLeft>1.41111 mm</tps:indentLeft> <tps:indentFirstLine>-1.41111 mm</tps:indentFirstLine> <tps:spaceAfter>2.11667 mm</tps:spaceAfter> <tps:nextStyle>affiliationnote</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>appendixhead</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>appendixhead</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>10.5 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>6.35 mm</tps:spaceBefore> <tps:spaceAfter>0.529167 mm</tps:spaceAfter> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>appendixtext</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>appendixtext</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentFirstLine>2.64583 mm</tps:indentFirstLine> <tps:nextStyle>appendixtext</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>appendixtext.first</tps:name> <tps:basedOn>appendixtext</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>appendixtext.first</tps:name> <tps:basedOn>appendixtext</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentFirstLine>0 mm</tps:indentFirstLine> <tps:nextStyle>appendixtext</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>attrib</tps:name> <tps:basedOn>extract</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>attrib</tps:name> <tps:basedOn>extract</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>0 mm</tps:spaceBefore> <tps:nextStyle>attrib</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>author</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>author</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> <tps:color> Black </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>4.23333 mm</tps:spaceBefore> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>author.signedby</tps:name> <tps:basedOn>author</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>author.signedby</tps:name> <tps:basedOn>author</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left</tps:alignment> <tps:spaceBefore>0 mm</tps:spaceBefore> <tps:nextStyle>author.signedby</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Banner1</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Banner1</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>33 pt</tps:fontSize> <tps:leading>29.75 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>Banner1</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Banner2</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Banner2</tps:name> <tps:font> <tps:name>OTNEJMQuadraatSmallCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:spaceBefore>7.05556 mm</tps:spaceBefore> <tps:nextStyle>Banner2</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>box_lbulleted1_f</tps:name> <tps:basedOn>kcp_caption</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>box_lbulleted1_f</tps:name> <tps:basedOn>kcp_caption</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>box_lbulleted1_f</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>box_lbulleted1_l</tps:name> <tps:basedOn>box_lbulleted1_m</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>box_lbulleted1_l</tps:name> <tps:basedOn>box_lbulleted1_m</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>box_lbulleted1_l</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>box_lbulleted1_m</tps:name> <tps:basedOn>box_lbulleted1_f</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>box_lbulleted1_m</tps:name> <tps:basedOn>box_lbulleted1_f</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>box_lbulleted1_m</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>boxtitle</tps:name> <tps:basedOn>tabletitle</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>boxtitle</tps:name> <tps:basedOn>tabletitle</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:indentRight>2.11667 mm</tps:indentRight> <tps:nextStyle>boxtitle</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>BRSummary</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>BRSummary</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceAfter>8.46667 mm</tps:spaceAfter> <tps:nextStyle>BRSummary</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Clinical Summary head1</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Clinical Summary head1</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>10.5 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>1.05833 mm</tps:spaceBefore> <tps:spaceAfter>0.352778 mm</tps:spaceAfter> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>copyright</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>copyright</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Italic</tps:style> </tps:font> <tps:fontSize>6 pt</tps:fontSize> <tps:leading>7 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:spaceBefore>0.705556 mm</tps:spaceBefore> <tps:nextStyle>copyright</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Copyright9</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Copyright9</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Italic</tps:style> </tps:font> <tps:fontSize>6 pt</tps:fontSize> <tps:leading>7 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:spaceBefore>0.705556 mm</tps:spaceBefore> <tps:nextStyle>Copyright9</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Copyright12</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Copyright12</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Italic</tps:style> </tps:font> <tps:fontSize>6 pt</tps:fontSize> <tps:leading>7 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:spaceBefore>0.705556 mm</tps:spaceBefore> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Corr_paragraph.first</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Corr_paragraph.first</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:nextStyle>paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Corr_paragraph.first_rule</tps:name> <tps:basedOn>Corr_paragraph.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>Corr_paragraph.first_rule</tps:name> <tps:basedOn>Corr_paragraph.first</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>4.23333 mm</tps:spaceBefore> <tps:nextStyle>paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>CorrTOC</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>CorrTOC</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>13 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>10.2306 mm</tps:indentLeft> <tps:indentFirstLine>-10.2306 mm</tps:indentFirstLine> <tps:spaceBefore>2.11667 mm</tps:spaceBefore> <tps:nextStyle>CorrTOC</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>CorrTOC_title</tps:name> <tps:basedOn>title</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>CorrTOC_title</tps:name> <tps:basedOn>title</tps:basedOn> <tps:font> <tps:name>OTNEJMScalaSansLFCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>CorrTOC_title</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>disclosure</tps:name> <tps:basedOn>supportedby</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>disclosure</tps:name> <tps:basedOn>supportedby</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>disclosure</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>DOI</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>DOI</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>7 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> <tps:color> Black65 </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:nextStyle>DOI</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>DOI.signedby</tps:name> <tps:basedOn>DOI</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>DOI.signedby</tps:name> <tps:basedOn>DOI</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>2.11667 mm</tps:spaceBefore> <tps:nextStyle>DOI.signedby</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>editor</tps:name> <tps:basedOn>author</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>editor</tps:name> <tps:basedOn>author</tps:basedOn> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> <tps:color> Black </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>0 mm</tps:spaceBefore> <tps:nextStyle>editor</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>End_author</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>End_author</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> <tps:color> Black </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>1.23472 mm</tps:spaceBefore> <tps:spaceAfter>4.23333 mm</tps:spaceAfter> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>End_head1</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>End_head1</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLFSmallCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>10.5 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>5.64444 mm</tps:spaceBefore> <tps:spaceAfter>3.52778 mm</tps:spaceAfter> <tps:nextStyle>End_head1</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>End_head1_2line</tps:name> <tps:basedOn>End_head1</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>End_head1_2line</tps:name> <tps:basedOn>End_head1</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>End_head1_2lineTOP</tps:name> <tps:basedOn>End_head1_2line</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>End_head1_2lineTOP</tps:name> <tps:basedOn>End_head1_2line</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceAfter>5.64444 mm</tps:spaceAfter> <tps:nextStyle>End_head1_2lineTOP</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>End_title</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>End_title</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>15.5 pt</tps:fontSize> <tps:leading>18 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>End_author</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>End_titlerule</tps:name> <tps:basedOn>End_title</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>End_titlerule</tps:name> <tps:basedOn>End_title</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>8.46667 mm</tps:spaceBefore> <tps:nextStyle>End_titlerule</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Equation_Single</tps:name> <tps:basedOn>extract</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>Equation_Single</tps:name> <tps:basedOn>extract</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>Equation_Single</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>extract</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>extract</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentLeft>4.23333 mm</tps:indentLeft> <tps:indentRight>4.23333 mm</tps:indentRight> <tps:spaceBefore>4.23333 mm</tps:spaceBefore> <tps:spaceAfter>4.23333 mm</tps:spaceAfter> <tps:nextStyle>paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>figurelegend</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>figurelegend</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>0.705556 mm</tps:spaceBefore> <tps:nextStyle>figurelegend</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>figuretitle</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>figuretitle</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>figurelegend</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>fill address</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>fill address</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>12.7 mm</tps:indentLeft> <tps:indentFirstLine>-8.46667 mm</tps:indentFirstLine> <tps:spaceBefore>1.05833 mm</tps:spaceBefore> <tps:spaceAfter>1.05833 mm</tps:spaceAfter> <tps:nextStyle>fill address</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>fill head</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>fill head</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceAfter>1.05833 mm</tps:spaceAfter> <tps:nextStyle>fill head</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>filladdress</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>filladdress</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>12.7 mm</tps:indentLeft> <tps:indentFirstLine>-8.46667 mm</tps:indentFirstLine> <tps:spaceBefore>1.05833 mm</tps:spaceBefore> <tps:spaceAfter>1.05833 mm</tps:spaceAfter> <tps:nextStyle>filladdress</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>FILLBOX left</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>FILLBOX left</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>FILLBOX left</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>FILLBOXleft</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>FILLBOXleft</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>FILLBOXleft</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>FillerHd</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>FillerHd</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> <tps:color> NEJM Red </tps:color> <tps:case>small</tps:case> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceAfter>0.352778 mm</tps:spaceAfter> <tps:nextStyle>FILLBOXleft</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>fillhead</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>fillhead</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceAfter>1.05833 mm</tps:spaceAfter> <tps:nextStyle>fillhead</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Folio</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Folio</tps:name> <tps:font> <tps:name>OTNEJMQuadraatCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>9.5 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>Folio</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>footer</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>footer</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLFCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.25 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>footer</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>foreword</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>foreword</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style>Italic</tps:style> </tps:font> <tps:fontSize>9 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>8.46667 mm</tps:spaceBefore> <tps:nextStyle>foreword</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head1</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>head1</tps:name> <tps:font> <tps:name>OTNEJMQuadraatSmallCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>10.5 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>5.64444 mm</tps:spaceBefore> <tps:spaceAfter>3.52778 mm</tps:spaceAfter> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head2</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>head2</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>9 pt</tps:fontSize> <tps:leading>10.5 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>4.40972 mm</tps:spaceBefore> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head2_2line</tps:name> <tps:basedOn>head2</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>head2_2line</tps:name> <tps:basedOn>head2</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head2_2line.after</tps:name> <tps:basedOn>head2_2line</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>head2_2line.after</tps:name> <tps:basedOn>head2_2line</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>0.176389 mm</tps:spaceBefore> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head2.after</tps:name> <tps:basedOn>head2</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>head2.after</tps:name> <tps:basedOn>head2</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>0.176389 mm</tps:spaceBefore> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head3</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>head3</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Italic</tps:style> </tps:font> <tps:fontSize>9.5 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>4.23333 mm</tps:spaceBefore> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head3.after</tps:name> <tps:basedOn>head3</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>head3.after</tps:name> <tps:basedOn>head3</tps:basedOn> <tps:leading>10.5 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>0.352778 mm</tps:spaceBefore> <tps:spaceAfter>0.352778 mm</tps:spaceAfter> <tps:nextStyle>paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head4</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>head4</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>9.5 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> <tps:color> Black </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentFirstLine>3.52778 mm</tps:indentFirstLine> <tps:nextStyle>head4</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>head4.after</tps:name> <tps:basedOn>head4</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>head4.after</tps:name> <tps:basedOn>head4</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>head4.after</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>indebtedto</tps:name> <tps:basedOn>supportedby</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>indebtedto</tps:name> <tps:basedOn>supportedby</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>indebtedto</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>kcp_caption</tps:name> <tps:basedOn>head2</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>kcp_caption</tps:name> <tps:basedOn>head2</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>2.11667 mm</tps:spaceBefore> <tps:spaceAfter>1.05833 mm</tps:spaceAfter> <tps:nextStyle>kcp_item</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>kcp_item</tps:name> <tps:basedOn>tablebody_0-12</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>kcp_item</tps:name> <tps:basedOn>tablebody_0-12</tps:basedOn> <tps:fontSize>8.5 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>kcp_item</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>kcp_label</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>kcp_label</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>10.5 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>1.05833 mm</tps:spaceBefore> <tps:spaceAfter>0.352778 mm</tps:spaceAfter> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>label.group</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>label.group</tps:name> <tps:font> <tps:name>Arial</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>0 pt</tps:leading> <tps:color> label </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>2.11667 mm</tps:spaceBefore> <tps:nextStyle>label.group</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>margintext</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>margintext</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Italic</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> <tps:color tint="100 %"> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>right justify</tps:alignment> <tps:nextStyle>margintext</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>paragraph</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>paragraph</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentFirstLine>4.23333 mm</tps:indentFirstLine> <tps:nextStyle>paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>paragraph.drop2</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>paragraph.drop2</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>paragraph.drop3</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>paragraph.drop3</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>paragraph.first</tps:name> <tps:basedOn>paragraph</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>paragraph.first</tps:name> <tps:basedOn>paragraph</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentFirstLine>0 mm</tps:indentFirstLine> <tps:nextStyle>paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>ParagraphFirst</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>ParagraphFirst</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:nextStyle>paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>presentedat</tps:name> <tps:basedOn>supportedby</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>presentedat</tps:name> <tps:basedOn>supportedby</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>presentedat</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>prod.label</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>prod.label</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>14 pt</tps:fontSize> <tps:leading>14 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>prod.label</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>prod.note</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>prod.note</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>prod.note</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>query</tps:name> <tps:basedOn>appendixhead</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>query</tps:name> <tps:basedOn>appendixhead</tps:basedOn> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style>Regular</tps:style> </tps:font> <tps:fontSize>10 pt</tps:fontSize> <tps:leading>0 pt</tps:leading> <tps:color> Black </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>query</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>references</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>references</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:nextStyle>references</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>references.balancer</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>references.balancer</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>0.1 pt</tps:fontSize> <tps:leading>0 pt</tps:leading> <tps:color> C=0 M=100 Y=0 K=0 </tps:color> </tps:charStyleDef> </tps:charStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>referenceshead</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>referenceshead</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>10.5 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>6.35 mm</tps:spaceBefore> <tps:spaceAfter>0.529167 mm</tps:spaceAfter> <tps:nextStyle>references</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>RefFillHead</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>RefFillHead</tps:name> <tps:font> <tps:name>NEJMScalaSansLF</tps:name> <tps:style>CapsBold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>RefFillHead</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>RefFillL</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>RefFillL</tps:name> <tps:font> <tps:name>NEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9.5 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>13.4056 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:spaceBefore>1.41111 mm</tps:spaceBefore> <tps:nextStyle>RefFillL</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>response</tps:name> <tps:basedOn>paragraph</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>response</tps:name> <tps:basedOn>paragraph</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>response</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>response.first</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>response.first</tps:name> <tps:basedOn>paragraph.first</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>4.23333 mm</tps:spaceBefore> <tps:nextStyle>response.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>runninghd</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>runninghd</tps:name> <tps:font> <tps:name>OTNEJMQuadraatSmallCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>8.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>runninghd</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>runninghdL</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>runninghdL</tps:name> <tps:font> <tps:name>OTNEJMQuadraatCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>9 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>SectionTitleEnd</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>SectionTitleEnd</tps:name> <tps:font> <tps:name>OTNEJMQuadraatSmallCap</tps:name> <tps:style/> </tps:font> <tps:fontSize>15 pt</tps:fontSize> <tps:leading>16 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceAfter>6.35 mm</tps:spaceAfter> <tps:nextStyle>title</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>SectionTitleFront</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>SectionTitleFront</tps:name> <tps:font> <tps:name>OTNEJMQuadraatSmallCap</tps:name> <tps:style/> </tps:font> <tps:leading>13 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>title</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>series-editors</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>series-editors</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>title</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>series-title</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>series-title</tps:name> <tps:font> <tps:name>OTNEJMScalaSansSmallLFCap</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>10.5 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>series-text</tps:name> <tps:basedOn>foreword</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>series-text</tps:name> <tps:basedOn>foreword</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>3.175 mm</tps:spaceBefore> <tps:nextStyle>series-text</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Slug</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Slug</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>9 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> <tps:color> Slug </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:nextStyle>Slug</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Source</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Source</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:spaceBefore>3.175 mm</tps:spaceBefore> <tps:nextStyle>Source</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>SourceNote</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>SourceNote</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentLeft>1.41111 mm</tps:indentLeft> <tps:indentFirstLine>-1.41111 mm</tps:indentFirstLine> <tps:spaceBefore>3.175 mm</tps:spaceBefore> <tps:nextStyle>SourceNote</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>stage</tps:name> <tps:basedOn>response</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>stage</tps:name> <tps:basedOn>response</tps:basedOn> <tps:font> <tps:name/> <tps:style>Bold</tps:style> </tps:font> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>stage.first</tps:name> <tps:basedOn>response.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>stage.first</tps:name> <tps:basedOn>response.first</tps:basedOn> <tps:font> <tps:name/> <tps:style>Bold</tps:style> </tps:font> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>stage</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Subtitle</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>Subtitle</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>13.5 pt</tps:fontSize> <tps:leading>15.5 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>1.41111 mm</tps:spaceBefore> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Summary text</tps:name> <tps:basedOn>figurelegend</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>Summary text</tps:name> <tps:basedOn>figurelegend</tps:basedOn> <tps:fontSize>8.5 pt</tps:fontSize> <tps:leading>12 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>Summary text</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>supportedby</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>supportedby</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>7.5 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>left justify</tps:alignment> <tps:indentFirstLine>2.82222 mm</tps:indentFirstLine> <tps:nextStyle>indebtedto</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>tablebody</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_0-12</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_0-12</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>4.23333 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_0-12</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_0-24</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_0-24</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>8.46667 mm</tps:indentLeft> <tps:indentFirstLine>-8.46667 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_0-24</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_0-36</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_0-36</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>12.7 mm</tps:indentLeft> <tps:indentFirstLine>-12.7 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_0-36</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_0-48</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_0-48</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>16.9333 mm</tps:indentLeft> <tps:indentFirstLine>-16.9333 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_0-48</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_12-24</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_12-24</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>8.46667 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_12-24</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_12-36</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_12-36</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>12.7 mm</tps:indentLeft> <tps:indentFirstLine>-8.46667 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_12-36</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_12-48</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_12-48</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>16.9333 mm</tps:indentLeft> <tps:indentFirstLine>-12.7 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_12-48</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_24-36</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_24-36</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>12.7 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_24-36</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_24-48</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_24-48</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>16.9333 mm</tps:indentLeft> <tps:indentFirstLine>-8.46667 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_24-48</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody_36-48</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody_36-48</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>16.9333 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablebody_36-48</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody-12</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody-12</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>8.46667 mm</tps:indentLeft> <tps:nextStyle>tablebody-12</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody-24</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody-24</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>12.7 mm</tps:indentLeft> <tps:nextStyle>tablebody-24</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody-36</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody-36</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>16.9333 mm</tps:indentLeft> <tps:nextStyle>tablebody-36</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody-char</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody-char</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>tablebody-char</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody.head</tps:name> <tps:basedOn>tablebody.paragraph.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody.head</tps:name> <tps:basedOn>tablebody.paragraph.first</tps:basedOn> <tps:font> <tps:name/> <tps:style>Bold</tps:style> </tps:font> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>1.05833 mm</tps:spaceBefore> <tps:nextStyle>tablebody.head</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody.paragraph</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody.paragraph</tps:name> <tps:basedOn>tablebody</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentFirstLine>4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablebody.paragraph</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablebody.paragraph.first</tps:name> <tps:basedOn>tablebody.paragraph</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablebody.paragraph.first</tps:name> <tps:basedOn>tablebody.paragraph</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentFirstLine>0 mm</tps:indentFirstLine> <tps:nextStyle>tablebody.paragraph.first</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>2.11667 mm</tps:indentLeft> <tps:indentFirstLine>-2.11667 mm</tps:indentFirstLine> <tps:nextStyle>tablefootnote</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote.double</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote.double</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>4.23333 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablefootnote.double</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote.first</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote.first</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceBefore>0.529167 mm</tps:spaceBefore> <tps:nextStyle>tablefootnote</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote.first.double</tps:name> <tps:basedOn>tablefootnote.first</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote.first.double</tps:name> <tps:basedOn>tablefootnote.first</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>4.58611 mm</tps:indentLeft> <tps:indentFirstLine>-4.23333 mm</tps:indentFirstLine> <tps:nextStyle>tablefootnote.first.double</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote.first.triple</tps:name> <tps:basedOn>tablefootnote.first.double</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote.first.triple</tps:name> <tps:basedOn>tablefootnote.first.double</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>6.35 mm</tps:indentLeft> <tps:indentFirstLine>-6.35 mm</tps:indentFirstLine> <tps:nextStyle>tablefootnote.first.triple</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote.spacer</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote.spacer</tps:name> <tps:basedOn>tablefootnote</tps:basedOn> <tps:fontSize>4.5 pt</tps:fontSize> <tps:leading>4.5 pt</tps:leading> <tps:color> None </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>tablefootnote.spacer</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablefootnote.triple</tps:name> <tps:basedOn>tablefootnote.double</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>tablefootnote.triple</tps:name> <tps:basedOn>tablefootnote.double</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>6.35 mm</tps:indentLeft> <tps:indentFirstLine>-6.35 mm</tps:indentFirstLine> <tps:nextStyle>tablefootnote.triple</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tablehead</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tablehead</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>tablehead</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tableheadA</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tableheadA</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>tableheadA</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tableheadB</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tableheadB</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style/> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>tableheadB</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tableheadC</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tableheadC</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Italic</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:nextStyle>tableheadC</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>tabletitle</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>tabletitle</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>10 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>2.11667 mm</tps:indentLeft> <tps:indentRight>1.41111 mm</tps:indentRight> <tps:spaceAfter>2.29306 mm</tps:spaceAfter> <tps:nextStyle>tabletitle</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>Paragraph Style 1</tps:name> <tps:basedOn>tabletitle</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>Paragraph Style 1</tps:name> <tps:basedOn>tabletitle</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:indentLeft>2.11667 mm</tps:indentLeft> <tps:indentRight>1.41111 mm</tps:indentRight> <tps:spaceAfter>2.29306 mm</tps:spaceAfter> <tps:nextStyle>Paragraph Style 1</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>title</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>title</tps:name> <tps:font> <tps:name>OTNEJMQuadraat</tps:name> <tps:style/> </tps:font> <tps:fontSize>18 pt</tps:fontSize> <tps:leading>20 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:alignment>center</tps:alignment> <tps:spaceBefore>4.23333 mm</tps:spaceBefore> <tps:nextStyle>author</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>webcallout</tps:name> <tps:charStyle> <tps:charStyleDef> <tps:name>webcallout</tps:name> <tps:font> <tps:name>OTNEJMScalaSansLF</tps:name> <tps:style>Bold Italic</tps:style> </tps:font> <tps:fontSize>8 pt</tps:fontSize> <tps:leading>9.5 pt</tps:leading> <tps:color> NEJM Red </tps:color> </tps:charStyleDef> </tps:charStyle> <tps:nextStyle>webcallout</tps:nextStyle> </tps:parStyleDef> </tps:definition> <tps:definition tag="parStyleDef"> <tps:parStyleDef> <tps:name>webcallout.graphic</tps:name> <tps:basedOn>webcallout</tps:basedOn> <tps:charStyle> <tps:charStyleDef> <tps:name>webcallout.graphic</tps:name> <tps:basedOn>webcallout</tps:basedOn> <tps:leading>0 pt</tps:leading> </tps:charStyleDef> </tps:charStyle> <tps:spaceAfter>1.41111 mm</tps:spaceAfter> <tps:nextStyle>webcallout.graphic</tps:nextStyle> </tps:parStyleDef> </tps:definition> <!-- ======================= --> <!-- Table Style Definitions --> <!-- ======================= --> <tps:definition tag="tableStyleDef"> <tps:tableStyleDef> <tps:name>Standard</tps:name> </tps:tableStyleDef> </tps:definition> <!-- ================================== --> <!-- Cross-reference Format Definitions --> <!-- ================================== --> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Full Paragraph &amp; Page Number</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Full Paragraph</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Paragraph Text &amp; Page Number</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Paragraph Text</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Paragraph Number &amp; Page Number</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Paragraph Number</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Text Anchor Name &amp; Page Number</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Text Anchor Name</tps:name> </tps:crossRefFormatDef> </tps:definition> <tps:definition tag="crossRefFormatDef"> <tps:crossRefFormatDef> <tps:name>Page Number</tps:name> </tps:crossRefFormatDef> </tps:definition> <!-- ======================= --> <!-- Master Page Definitions --> <!-- ======================= --> <tps:definition tag="masterSpreadDef"> <tps:masterSpreadDef> <tps:name>A-OA_opener</tps:name> <tps:pageInfo classifier="0"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="10.9361 mm" right="21.8722 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame type="mainStoryFrame"/> <tps:frame name="alt-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="article-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="abstract" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="aff" type="element"> <tps:frame type="contentFrame"/> </tps:frame> </tps:frames> </tps:pageInfo> <tps:pageInfo classifier="1"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="21.8722 mm" right="10.9361 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame type="mainStoryFrame"/> <tps:frame name="alt-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="article-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="abstract" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="aff" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="prod-note" type="element"> <tps:frame type="contentFrame"/> </tps:frame> </tps:frames> </tps:pageInfo> </tps:masterSpreadDef> </tps:definition> <tps:definition tag="masterSpreadDef"> <tps:masterSpreadDef> <tps:name>B-OA_firstopener</tps:name> <tps:pageInfo classifier="0"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="10.9361 mm" right="21.8722 mm" bottom="27.8694 mm"/> </tps:pageInfo> <tps:pageInfo classifier="1"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="21.8722 mm" right="10.9361 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame type="mainStoryFrame"/> <tps:frame name="alt-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="article-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="abstract" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="aff" type="element"> <tps:frame type="contentFrame"/> </tps:frame> </tps:frames> </tps:pageInfo> </tps:masterSpreadDef> </tps:definition> <tps:definition tag="masterSpreadDef"> <tps:masterSpreadDef> <tps:name>C-RA_opener</tps:name> <tps:pageInfo classifier="0"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="10.9361 mm" right="21.8722 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame type="mainStoryFrame"/> <tps:frame name="alt-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="article-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> <tps:frame name="aff" type="element"> <tps:frame type="contentFrame"/> </tps:frame> </tps:frames> </tps:pageInfo> <tps:pageInfo classifier="1"> <tps:size width="200.025 mm" height="266.7 mm"/> <tps:margins top="19.4028 mm" left="21.8722 mm" right="10.9361 mm" bottom="27.8694 mm"/> <tps:frames> <tps:frame type="mainStoryFrame"/> <tps:frame name="alt-title" type="element"> <tps:frame type="contentFrame"/> </tps:frame> 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