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Case Records of the Massachusetts General HospitalFree Preview

Case 4-2021: A 70-Year-Old Woman with Dyspnea on Exertion and Abnormal Findings on Chest Imaging

List of authors.
  • Richard M. Schwartzstein, M.D.,
  • Benjamin D. Medoff, M.D.,
  • Amita Sharma, M.D.,
  • Yolonda L. Colson, M.D.,
  • Justin Gainor, M.D.,
  • and Lida P. Hariri, M.D., Ph.D.

A 70-year-old woman was evaluated because of increasing dyspnea on exertion and abnormal findings on chest imaging. Eleven years before this evaluation, mild mosaic attenuation at the lung bases was identified incidentally. Three years later, dyspnea on exertion developed and pulmonary function worsened. Diagnostic tests were performed.

Funding and Disclosures

This case was presented at Pulmonary Grand Rounds.

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org.

Dr. Medoff reports receiving grant support from Bayer, Boehringer Ingelheim, and Bristol Myers Squibb and serving on an advisory board for Sanofi; Dr. Sharma, receiving grant support from Hummingbird Diagnostics; Dr. Colson, receiving grant support from Canon USA and equipment provision from StrykerCNOVADAQ; Dr. Gainor, receiving consulting fees from Bristol Myers Squibb, Merck, GenentechCRoche, AstraZeneca, Pfizer, LoxoCLilly, Blueprint, Regeneron, Gilead, Jounce, Amgen, Array, Oncorus, EMD Serono, and Mirati and grant support and consulting fees from Takeda and Novartis; and Dr. Hariri, receiving grant support, advisory board fees, and lecture fees from Boehringer Ingelheim and consulting fees from Pliant Therapeutics and Biogen. No other potential conflict of interest relevant to this article was reported.

Author Affiliations

From the Department of Medicine, Beth Israel Deaconess Medical Center (R.M.S.), the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Massachusetts General Hospital, and the Departments of Medicine (B.D.M., J.G.), Radiology (A.S.), Surgery (Y.L.C.), and Pathology (L.P.H.), Harvard Medical School all in Boston.

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