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Diffuse Large B-Cell Lymphoma

To the Editor: With regard to the extensive and detailed review article on diffuse large B-cell lymphoma by Sehn and Salles (March 4 issue),1 we are disappointed that the authors devoted little attention to the association between diffuse large B-cell lymphoma and human immunodeficiency virus (HIV) infection. HIV infection is an important risk factor for non-Hodgkins lymphoma, an acquired immunodeficiency syndromeCdefining cancer (the most common of which is diffuse large B-cell lymphoma).2 Between 2005 and 2009, persons with HIV infection had approximately a 1 in 25 chance of the development of non-Hodgkins lymphoma3; this risk was 10 to 20 times . . .

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